In vitro modeling of the post-ingestion mobilization and bioaccessibility of pesticides sorbed to soil and house dust.

ABSTRACT: Soils and dusts can act as sinks for semivolatile lipophilic organic compounds and children ingest relatively large amounts of both soils and dusts. Following intake, sorbed chemicals may desorb (mobilize) and become available for intestinal absorption (bioaccessible). When chemicals are not degraded in the digestive tract, mobilization can approximate bioaccessibility. Alternatively, when gastrointestinal degradation of mobilized chemicals does occur, it can be useful to separate mobilization from bioaccessibility. In this study we used synthetic digestive fluids in a sequential, three-compartment (saliva, gastric, and intestinal) in vitro assay to construct mobilization and bioaccessibility models for 16 pesticides (log K_ow 2.5-6.8) sorbed to 32 characterized soils and house d

SUBMITTER: Starr JM 

PROVIDER: S-EPMC11869559 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature