Admixture as a source for HLA variation in Neolithic European farming communities.

ABSTRACT:

Background

The northern European Neolithic is characterized by two major demographic events: immigration of early farmers from Anatolia at 7500 years before present, and their admixture with local western hunter-gatherers forming late farmers, from around 6200 years before present. The influence of this admixture event on variation in the immune-relevant human leukocyte antigen (HLA) region is understudied.

Results

We analyzed genome-wide data of 125 individuals from seven archeological early farmer and late farmer sites located in present-day Germany. The late farmer group studied here is associated with the Wartberg culture, from around 5500-4800 years before present. We note that late farmers resulted from sex-biased admixture from male western hunter-gatherers. In additi

SUBMITTER: da Silva NA 

PROVIDER: S-EPMC11869582 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature