Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy.

ABSTRACT:

Background

Gut microbiota-derived urolithins may influence multiple myeloma (MM) disease progression and treatment. We analyzed urolithins and their associated microbiota in a retrospective cohort of 45 patients with active MM or premalignant disease using mass spectrometry and 16S rRNA gene sequencing.

Results

Patients with detectable levels of urolithin in serum and stool and a higher abundance of urolithin-related microbiota had a better outcome. Analysis of the effects of urolithin A (UroA) treatment ex vivo, in vitro, and in vivo revealed that UroA is cytotoxic against MM cell lines and modulates the cell cycle and mitochondrial activity. Notably, UroA inhibits the proliferation of primary MM cells in vitro and in a xenograft mouse model, improving overall survival. Fin

SUBMITTER: Rodriguez-Garcia A 

PROVIDER: S-EPMC11869585 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature