Clinical and economic burden of achondroplasia in the United States: results from a retrospective, observational study.

ABSTRACT:

Background

Achondroplasia, a disease characterized by disproportionate short stature and increased morbidity, affects daily function and quality of life over the lifetime of the individual. However, data are limited on its economic impact, especially related to healthcare resource utilization (HCRU) and associated costs. This study aimed to characterize the clinical and economic impact of achondroplasia in the US relative to matched non-achondroplasia controls stratified by pediatric and adult populations.

Methods

This retrospective study used data from the IQVIA PharMetrics Plus national claims database from January 2008 to December 2021. Individuals diagnosed with achondroplasia (index event) between July 2008 and December 2020 were matched on age and sex (1:2 ratio) to no

SUBMITTER: Merchant N 

PROVIDER: S-EPMC11869590 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature