Finding high posterior density phylogenies by systematically extending a directed acyclic graph.

ABSTRACT: Bayesian phylogenetics typically estimates a posterior distribution, or aspects thereof, using Markov chain Monte Carlo methods. These methods integrate over tree space by applying local rearrangements to move a tree through its space as a random walk. Previous work explored the possibility of replacing this random walk with a systematic search, but was quickly overwhelmed by the large number of probable trees in the posterior distribution. In this paper we develop methods to sidestep this problem using a recently introduced structure called the subsplit directed acyclic graph (sDAG). This structure can represent many trees at once, and local rearrangements of trees translate to methods of enlarging the sDAG. Here we propose two methods of introducing, ranking, and selecting local rearrang

SUBMITTER: Jennings-Shaffer C 

PROVIDER: S-EPMC11869616 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature