Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury.

ABSTRACT:

Introduction

Spinal cord injury (SCI) impairs the balance of gut microbiomes, which further aggravates inflammation in the injured areas and inhibits axonal regeneration. The intestinal microbiome plays an important role in SCI and regulating intestinal microbiome promotes SCI repair. However, current studies have shown that indole-3 propionate (IPA), a metabolite of gut bacteria, can promote axonal regeneration. However, the short half-life of IPA limits its effectiveness. Gut microbiota plays a role in the progression of SCI, but the studies about diet regulates intestinal flora metabolites to improve SCI are still limited and lack guiding significance.

Results

The results showed that Pectin-Zein-IPA NPs treatment improves motor function recovery, inhibits the activation o

SUBMITTER: Chen X 

PROVIDER: S-EPMC11869623 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature