Volume kinetics in a translational porcine model of stabilized sepsis with fluid accumulation.

ABSTRACT:

Background

Fluid dynamics during and after a septic event is complex, but better knowledge could guide both fluid resuscitation and fluid removal. We aimed to compare fluid dynamics before and after sepsis in a clinically relevant mono-bacterial porcine model.

Methods

Twelve sows with a mean body weight of 56 kg were anesthetized, mechanically ventilated, and invasively monitored. Sepsis was induced with an intravenous infusion of P. aeruginosa. Animals were resuscitated during the acute septic phase according to a protocolized algorithm. Volume kinetics was studied before the bacterial infusion (baseline) and 24 h later (late sepsis), and both consisted of an infusion of 1,500 mL of 0.9% saline over 20 min with repeated hemoglobin and albumin measurements and urine quantifi

SUBMITTER: Hong SL 

PROVIDER: S-EPMC11869627 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature