Extinction of contextual fear memory is facilitated in TRPM2 knockout mice.

ABSTRACT: Transient receptor potential melastatin type 2 (TRPM2) is a nonselective cation channel involved in synaptic plasticity. We investigated its role in contextual fear conditioning and extinction of conditioned fear using Trpm2-deficient (Trpm2^-/-) mice. Trpm2^-/- mice exhibited reduced acquisition of contextual fear memory during conditioning but had an intact freezing response to conditioning context 24 h after conditioning. They also showed a reduced freezing response to extinction training, indicating facilitated extinction. Consistent with this, infusion of flufenamic acid (FFA), a TRPM2 antagonist, into the dentate gyrus (DG) of the hippocampus in fear-conditioned mice facilitated extinction of contextual fear. The enhanced extinction in Trpm2^-/- and FFA-

SUBMITTER: Ko SY 

PROVIDER: S-EPMC11869647 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature