Identification of E3 ubiquitin ligase-based molecular subtypes and prognostic signature regarding prognosis and immune landscape in bladder cancer.

ABSTRACT: E3 ubiquitin ligases are acknowledged as the principal catalysts in the ubiquitination process due to their capacity to identify, bind and recruit specific substrates for modification. However, knowledge about the expression patterns of E3 ligases and their contribution to the tumor heterogeneity of bladder cancer (BLCA) is still lacking. Here, we delineated two distinct subcategories of BLCA utilizing consensus clustering of variable expression patterns of E3 ligases from the TCGA database, outlining the functional characteristics and immune profiles of these subclusters. Crucially, these clusters offered valuable perspectives on the tumor immune microenvironment (TIME) and tumor response to immunotherapy. Additionally, we established and validated an E3 ligase-related prognostic model pr

SUBMITTER: Hu B 

PROVIDER: S-EPMC11869681 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature