Enterocloster clostridioformis protects against Salmonella pathogenesis and modulates epithelial and mucosal immune function.

ABSTRACT:

Background

Promoting resistance to enteric pathogen infection is a core function of the gut microbiota; however, many of the specific host-commensal interactions that mediate this protection remain uncharacterised. To address this knowledge gap, we monocolonised germ-free mice with mouse-derived commensal microbes to screen for microbiota-induced resistance to Salmonella Typhimurium infection.

Results

We identified Enterocloster clostridioformis as a protective species against S. Typhimurium infection. E. clostridioformis selectively upregulates resistin-like molecule β and cell cycle pathway expression at the level of caecal epithelial cells and increases T-regulatory cells in the underlying mucosal immune system, potentially contributing to reduced infection-induced pathol

SUBMITTER: Beresford-Jones BS 

PROVIDER: S-EPMC11869688 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature