Lower immune senescence of T cell subsets among virologically suppressed Chinese men who have sex with men living with HIV in comparison with those ART naive.

ABSTRACT:

Background

Immune senescence can occur in untreated HIV infection and is partially reversible with effective antiretroviral therapy (ART). Here, we investigated the differences in immune senescence of T cell subsets among Chinese men who have sex with men (MSM) living with HIV virologically suppressed on ART compared to those ART-naive.

Methods

A cohort of MSM living with HIV with different disease courses was included, untreated viral non-controllers (n = 26) and those on ART (n = 30). The percentages of naive, central memory (TCM), effector memory (TEM), and terminally differentiated memory (TemRA) subsets of CD4 and CD8 T cells were studied, along with markers of senescence (CD28-CD57+) and activation (HLA-DR). Telomere length of naive and memory CD8 T cells was quantifie

SUBMITTER: Li L 

PROVIDER: S-EPMC11869689 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature