Microtubule-modulating drugs alter sensitivity to isoflurane in mice.

ABSTRACT:

Background

Microtubules (MTs) have been postulated as one of the molecular targets underlying loss of consciousness induced by inhalational anesthetics. Microtubule-targeting chemotherapy drugs and opioids affect MT stability and function. However, the impact of prolonged administration of these drugs on anesthetic potency and anesthesia induction and emergence times remain unelucidated.

Methods

Epothilone D, paclitaxel, vinblastine or opioid morphine were administered alone for a prolonged period (> 2 weeks) to male CD1 mice and their sensitivity to incremental concentrations of isoflurane were examined using loss of righting reflex (LORR) response as a measure of sensivity. The induction and emergence time after administration and termination of fixed concentration of isof

SUBMITTER: Li N 

PROVIDER: S-EPMC11869693 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature