Developing a PK-PD model for propofol in exhaled air and the BIS following fospropofol disodium in beagles.

ABSTRACT:

Background

Fospropofol, a water-soluble prodrug of propofol, is metabolized into propofol by alkaline phosphatase after administration. This study aimed to develop a pharmacokinetic-pharmacodynamic (PK-PD) model that correlates the propofol concentration in exhaled air (Ce-pro-f) with its anesthetic effects, as measured by the bispectral index (BIS) in beagles.

Methods

Beagles receiving a single intravenous infusion of fospropofol at varying doses were divided into three groups (n = 6): the DBL-fospro group (15 mg/kg), the DBM-fospro group (30 mg/kg), and the DBH-fospro group (60 mg/kg). Propofol levels were monitored using VUV-TOF MS from pre-administration to recovery. Correlations between Ce-pro-f and blood concentration (C_blood-pro), as well as between Ce-pro-

SUBMITTER: Li X 

PROVIDER: S-EPMC11869703 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature