Causal Relationship Between Air Pollutants and Blood Pressure Phenotypes: A Mendelian Randomization Study.

ABSTRACT:

Objectives

Hypertension is a chronic disease widely prevalent around the world. While previous observational studies have suggested a link between air pollutants and an increased risk of hypertension, causality has not been established. Our study aimed to investigate potential causal relationships between five air pollutants and four blood pressure phenotypes through two-sample Mendelian randomization.

Methods

Two-sample Mendelian randomization (MR) analyses were performed using genome-wide association studies (GWAS) data from the IEU OpenGWAS project. The main analysis method was the inverse variance weighting (IVW) method. Heterogeneity was assessed by Cochran's Q test, while pleiotropy was assessed by MR-Egger regression. Sensitivity analysis was performed by weighted med

SUBMITTER: Zhu X 

PROVIDER: S-EPMC11869833 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature