Real-world enrollment for a prospective clinico-genomic database using a pragmatic technology-enabled platform.

ABSTRACT:

Background

Discovery and incorporation of predictive and prognostic biomarkers enhance outcomes for patients with cancer. Clinico-genomic datasets, which retrospectively link real-world clinical data to tumor sequencing data, are important resources for biomarker research, which has historically relied on robust research infrastructures exclusive to large academic centers. The objective was to evaluate the feasibility of a pragmatic, technology-enabled platform at community-based research sites for development of a prospective clinico-genomic database supported by centralized electronic health record (EHR)-based patient ascertainment and data processing.

Methods

Adults with stage IV or recurrent metastatic non-small cell lung cancer or extensive-stage small-cell lung cancer

SUBMITTER: Exarchos A 

PROVIDER: S-EPMC11869879 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature