Carbon dioxide alleviates platelet storage lesions via stimulating fatty acid metabolism and reducing platelet glucose consumption.

ABSTRACT:

Background

The timely administration of platelet transfusions is critical for patient survival, and the clinical demand for platelet transfusions has been steadily increasing. However, platelet storage lesions (PSLs) that develop during in vitro preservation exacerbate these shortages. The PSL is significantly influenced by various factors, including temperature, gas composition, and buffering systems. Strategies to mitigate PSLs and improve platelet storage have been actively explored in recent years.

Objectives

This study aimed to investigate whether elevated carbon dioxide (CO₂) levels improve platelet quality and functionality during storage.

Methods

Platelet concentrates from 28 donors were stored under control or 3% CO₂ conditions at

SUBMITTER: Gu S 

PROVIDER: S-EPMC11869954 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature