Role of molecular alterations in transplantation decisions for patients with primary myelofibrosis.

ABSTRACT:

Abstract

The aim of our study was to analyze the potential survival benefit associated with hematopoietic stem cell transplantation (HSCT) according to clinicobiological scores, which incorporate mutation-enhanced international prognostic score system (MIPSS) to facilitate decision-making in this context. One transplant (n = 241) and 1 nontransplant cohort (n = 239) were used to test the hypothesis that patients with primary myelofibrosis with higher risk molecular score benefit from HSCT. A weighted propensity score was applied to balance confounding factors with the transplanted cohort as reference. Weighted Cox proportional hazard models and logistic regression analyses were performed. Overall, 105 patients who did not receive transplant could be matched to the 239 patients who

SUBMITTER: Luque Paz D 

PROVIDER: S-EPMC11869958 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature