The effect of radiation dose to the brain on early self-reported cognitive function in brain and head-and-neck cancer patients.

ABSTRACT:

Purpose

Assess cognitive changes after radiotherapy (RT) in brain and head-and-neck (HN) cancer patients using patient-reported outcome measures (PROMs) and evaluate a dose-effect relationship for brain structures.

Materials and methods

Primary brain and HN cancer patients treated with RT between 2012-2021 were included. Patient characteristics, clinical parameters, and PROMs at baseline and 1-year follow-up were collected. Cognitive functioning (CF) from the EORTC QLQ-C30, communication deficit (CD) from the QLQ-BN20, and one cognition-related questions from the EQ6D questionnaire were used, the latter two only for brain patients. Missing data were imputed and the four-point scale scores were transformed to a 100-point scale. Change in scores from baseline to 1-year were ca

SUBMITTER: Vaassen F 

PROVIDER: S-EPMC11869991 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature