Increased muscle satellite cell content and preserved telomere length in response to combined exercise training in patients with FSHD.

ABSTRACT: Facioscapulohumeral muscular dystrophy (FSHD) is an inherited muscle disease characterized by weakness and muscle wasting. In the absence of available treatments, exercise training has emerged as a potential strategy to attenuate muscle tissue deterioration. However, little is known about the impact of chronic exercise on degenerative events and regenerative capacity in FSHD muscle. Muscle biopsies were obtained from 16 FSHD patients before and after a 24 week training program combining aerobic-, strength- and high-intensity exercise (Control; n = 8, Training; n = 8). Histochemical and immunohistochemical approaches were applied to assess histopathological signs, markers of regeneration, inflammatory infiltrates and satellite cell content. Muscle telomere length was measured as an indicato

SUBMITTER: Horwath O 

PROVIDER: S-EPMC11870062 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature