Circulating Growth Differentiation Factor 15 (GDF15) in Paediatric Disease: A Systematic Review.

ABSTRACT:

Background

Growth Differentiation Factor 15 (GDF15), a nonspecific inflammatory marker and member of the TGF-β superfamily, has a well-established role in both inflammation and metabolic modulation, but lacks a comprehensive paediatric literature review. In several adult disease states, including cancer cachexia and pregnancy, circulation and expression of GDF15 has been of clinical and scientific interest, but little published paediatric data exists. As such, we aim to summarize existing paediatric studies.

Methods

This review follows the PRISMA-ScR guidelines for reporting and aims to summarize existing paediatric studies including GDF15, describe disease entities in which GDF15 has been investigated including existing reference ranges, and identify literature gaps to pres

SUBMITTER: Kronenberger DW 

PROVIDER: S-EPMC11870081 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature