A tumor-targeting black phosphorus-based nanoplatform for controlled chemo-photothermal therapy of breast cancer.

ABSTRACT: Combination therapy with high efficacy and precision shows great potential in breast cancer treatment. Herein, we developed a multifunctional nanocarrier (NBP@mSiO₂-PEG-cRGD) for tumor-targeting chemo-photothermal therapy of breast cancer in a controlled manner. The nanocarrier was constructed by enveloping nano-sized black phosphorus (NBP) within a mesoporous silica shell (mSiO₂) modified with the tumor-targeting peptide c(Arg-Gly-Asp-dPhe-Cys) (cRGD). Due to the existence of pore channels within mSiO₂, NBP@mSiO₂-PEG-cRGD achieved high loading efficiency of indole-3-carbinol (I3C) molecules (NBP@mSiO₂-PEG-cRGD/I3C), an anti-tumor agent derived from food. Mediated by cRGD/integrin αvβ3 interaction, NBP@mSiO₂-PEG-cRGD/I3C rea

SUBMITTER: Yang L 

PROVIDER: S-EPMC11870200 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature