Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity.

ABSTRACT: Ageing of the immune system is characterized by decreased lymphopoiesis and adaptive immunity, and increased inflammation and myeloid pathologies^1,2. Age-related changes in populations of self-renewing haematopoietic stem cells (HSCs) are thought to underlie these phenomena³. During youth, HSCs with balanced output of lymphoid and myeloid cells (bal-HSCs) predominate over HSCs with myeloid-biased output (my-HSCs), thereby promoting the lymphopoiesis required for initiating adaptive immune responses, while limiting the production of myeloid cells, which can be pro-inflammatory⁴. Ageing is associated with increased proportions of my-HSCs, resulting in decreased lymphopoiesis and increased myelopoiesis^3,5,6. Transfer of bal-HSCs results in abundant

SUBMITTER: Ross JB 

PROVIDER: S-EPMC11870232 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature