The viral landscape in metastatic solid cancers.

ABSTRACT: Here, we analyze the viral landscape in blood and tissue from 4918 metastatic cancer patients across 38 solid cancer types from the Hartwig Medical Foundation (HMF) cohort, the largest pan-cancer study on metastatic cancer. Using a coverage-based filtering approach, we detected 25 unique viral genera across 32 different cancer types, with a total of 747 unique virus-positive tissue samples. We detected 336 virus-positive blood samples across 29 cancer types, dominated by Torque teno virus and Alphatorquevirus. The tissue samples were dominated by Alphapapillomavirus and Roseolovirus. Alphapapillomavirus was significantly enriched in genital, anal, and colorectal cancers and was associated with host mutational signatures and transcriptional programs relate

SUBMITTER: Mjelle R 

PROVIDER: S-EPMC11870251 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature