Nicotine Influence on Vascular and Neurocognitive Function with In-utero Electronic Cigarette Exposure.

ABSTRACT: Emerging studies find arteriolar dysfunction in offspring with in-utero electronic cigarette (Ecig) exposure, but the long-term effect on offspring's cerebrovascular vascular and neurocognitive health is poorly understood. Ecigs provides a unique opportunity to directly evaluate the contributions of inhaled nicotine from the vehicle e-liquid - which was not possible with traditional cigarettes. Moreover, many Ecigs have variable power settings, which can alter the toxicity of the aerosol cloud produced. We hypothesize maternal vaping at different wattages will have variable effects on cerebrovascular function in the offspring, and that these effects would be independent of nicotine. We used time-mated female Sprague-Dawley rats with Ecig exposure from gestation day (GD)2-21. We studied mal

SUBMITTER: Mills A 

PROVIDER: S-EPMC11870428 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature