Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility.

ABSTRACT: The native microbiome influences a plethora of host processes, including neurological function. However, its impacts on diverse brain cell types remains poorly understood. Here, we performed single nucleus RNA sequencing on hippocampi from wildtype, germ-free mice and reveal the microbiome-dependent transcriptional landscape across all major neural cell types. We found conserved impacts on key adaptive immune and neurodegenerative transcriptional pathways, underscoring the microbiome's contributions to disease-relevant processes. Mono-colonization with select indigenous microbes identified species-specific effects on the transcriptional state of brain myeloid cells. Colonization by Escherichia coli induced a distinct adaptive immune and neurogenerative disease-associated cell state,

SUBMITTER: Blackmer-Raynolds L 

PROVIDER: S-EPMC11870502 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature