Cholesterol efflux protein, ABCA1, supports anti-cancer functions of myeloid immune cells.

ABSTRACT: Although immune therapy has seen significant advances, the majority of breast and other solid tumors do not respond or quickly develop de novo resistance. One factor driving resistance is highly immune suppressive myeloid cells (MCs) such as macrophages. Previous work has established clinical links between cholesterol and cancer outcome, and that MC function can be regulated through disruption in cholesterol metabolism. Thus, we screened for proteins that were expressed in MCs, involved in cholesterol homeostasis and whose expression was associated with survival; we identify the cholesterol efflux protein ABCA1. Preclinical studies revealed that ABCA1 activity resulted in increased anti-cancer functions of macrophages: enhanced tumor infiltration, decreased angiogenic potential, red

SUBMITTER: Bendre SV 

PROVIDER: S-EPMC11870514 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature