The architecture, assembly, and evolution of a complex flagellar motor.

ABSTRACT: Bacterial flagella drive motility in many species, likely including the last bacterial common ancestor^1,2. Knowledge of flagellar assembly and function has mainly come from studies of Escherichia coli and Salmonella enterica, which have simple flagellar motors^3-7. However, most flagellated bacteria possess complex motors with unique, species-specific adaptations whose mechanisms and evolution remain largely unexplored^8-10. Here, we deploy a multidisciplinary approach to build a near-complete model of the flagellar motor in Campylobacter jejuni, revealing its remarkable complexity in architecture and composition. We identify an E-ring around the MS-ring, a periplasmic cage with two distinctive conformations, and an intricate interaction

SUBMITTER: Feng X 

PROVIDER: S-EPMC11870540 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature