A model for background selection in non-equilibrium populations.

ABSTRACT: In many taxa, levels of genetic diversity are observed to vary along their genome. The framework of background selection models this variation in terms of linkage to constrained sites, and recent applications have been able to explain a large portion of the variation in human genomes. However, these studies have also yielded conflicting results, stemming from two key limitations. First, existing models are inaccurate in a critical region of parameter space ( Nes~-1 ), where the local reduction in diversity is sharpest. Second, they assume a constant population size over time. Here, we develop predictions for diversity under background selection based on the Hill-Robertson system of two-locus statistics, which allows for population size changes. We treat the joint effect of multiple selecte

SUBMITTER: Barroso GV 

PROVIDER: S-EPMC11870586 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature