Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans.

ABSTRACT: Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features in humans remain poorly understood. Here we performed machine learning-augmented analysis of published single-cell RNA-sequencing datasets and identified macaque imGCs with transcriptome-wide immature neuronal characteristics. Our cross-species comparisons among humans, monkeys, pigs, and mice showed few shared (such as DPYSL5), but mostly species-specific gene expression in imGCs that converged onto common biological processes regulating neuronal development. We further identified human-specific transcriptomic features of imGCs and demonstrated functional roles of human imGC-enriched express

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11870590 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature