Ciliated cell domains with locally coordinated ciliary motion generate a mosaic of microflows in the brain's lateral ventricles.

ABSTRACT: Circulation of cerebrospinal fluid (CSF) through the brain's ventricles is essential for maintaining brain homeostasis and supporting neurogenesis. CSF flow is supported by the structural polarization of multiciliated cells, which align with the flow direction. However, it remains unclear how the organization of tissue-wide polarity across the ciliary epithelium comprised of thousands of cells, determines the trajectory of the flow and efficient distribution of the CSF. Here, we used new approaches to analyze the organization of translational polarity across extensive areas of the lateral ventricular wall. We also used live imaging to examine cilia motion, flow trajectories, and ciliary beat frequency (CBF) in live preparations of ventricles. In addition to the primary flow running across

SUBMITTER: Mellanson K 

PROVIDER: S-EPMC11870595 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature