Identification of human ccn2 (connective tissue growth factor) promoter polymorphisms.

ABSTRACT:

Background

Connective tissue growth factor (CCN2; CTGF) is a newly identified growth factor, which is involved in the regulation of wound repair and fibrosis. Because there is variation among individuals with respect to tissue response to injury, genetic factors might be involved in the final outcome of tissue repair or scarring. For example, polymorphisms in the promoter region of genes, such as those encoding transforming growth factor beta1 (TGF-beta1), interleukin 10 (IL-10), and tumour necrosis factor alpha (TNF-alpha), influence transcriptional responses and are thought to contribute to the dysregulation of these genes in pathological conditions.

Aim

To investigate whether the promoter region of the ccn2 (ctgf) gene contains polymorphic sequences that might account for

SUBMITTER: Blom IE 

PROVIDER: S-EPMC1187061 | biostudies-literature | 2001 Jun

REPOSITORIES: biostudies-literature