Clonal interference, genetic variation and the speed of evolution in structured populations.

ABSTRACT: When it comes to understanding the role that population structure plays in shaping rates of evolution, it is commonly accepted that interference between evolutionary innovations is more prevalent in structured populations compared to well-mixed, and that population structure reduces the rate of evolution, while simultaneously promoting maintenance of genetic variation. Prior models usually represent population structure using two or more connected demes or lattices with periodic boundary conditions. Fundamentally, the observed spatial evolutionary slow-down is rooted in the fact that these types of structures increase the time it takes for a selective sweep and therefore, increase the probability that multiple beneficial mutations will coexist and interfere. Here we show that systematicall

SUBMITTER: Kuo YP 

PROVIDER: S-EPMC11870626 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature