Cognitive Outcomes in Myelin Oligodendrocyte Glycoprotein-IgG Associated Disease Compared to Multiple Sclerosis.

ABSTRACT:

Background

Little is known about cognitive outcomes in people with myelin oligodendrocyte glycoprotein-IgG associated disease (pwMOGAD). While there are similarities between MOGAD and multiple sclerosis (MS), further evaluation is needed to establish the distinct cognitive trajectories for each disease.

Methods

Retrospective review of subjective cognitive changes was performed for adult pwMOGAD. Subsets of pwMOGAD completed a cognitive screening measure and/or comprehensive neuropsychological testing. Their performance was compared to age, sex, and race matched people with MS (pwMS; 3:1 ratio).

Results

Approximately half (51.6%) of pwMOGAD (n = 63) endorsed cognitive dysfunction. On a cognitive screening measure (Processing Speed Test [PST]), performance did not stati

SUBMITTER: Galvani E 

PROVIDER: S-EPMC11870788 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature