Post-Thrombectomy Mild Hypercapnia State Prevents Poor Outcome by Reducing Infarct Progression.

ABSTRACT:

Objective

In endovascular therapy (EVT) for stroke, futile recanalization contributes to poor prognosis. Mild hypercapnia may enhance cerebral blood flow and prevent ischemia, but its impact on prognosis in successfully recanalized EVT patients is unclear.

Methods

We retrospectively analyzed 237 patients from the INSPIRE database who underwent successful recanalization at our center (October 2018-March 2022). Patients were grouped by post-EVT PaCO₂ levels: high (40-50 mmHg) and low (<40 mmHg). Significant infarct expansion (SIE) was defined as a decrease in ASPECTS or pc-ASPECTS by ≥2 from initial to 3-5 days post-EVT. Poor outcome was modified Rankin Scale score 3-6 at 90 days.

Results

High PaCO₂ was negatively associated with SIE (OR 0.42, 95%

SUBMITTER: Jiang P 

PROVIDER: S-EPMC11870790 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature