A Preliminary Study of Effect of Melatonin on Inflammation and Hypoxia-Related Factors in a Mouse Model of Elastase-Induced Intracranial Aneurysm.

ABSTRACT:

Introduction

Intracranial aneurysms (IAs) are relatively common cerebrovascular anomalies. Melatonin could modulate inflammatory and offers neuroprotective effects, and its role in IA has not been fully elucidated.

Methods

An elastase-induced IA mouse model was constructed and melatonin (150 mg/kg) was administered to investigate its therapeutic effects on IA. Aneurysm formation was observed by bromophenol blue gelatin perfusion, and the pathology changes in IA mice were examined using hematoxylin-eosin (HE) staining. The potential mechanisms of melatonin treatment of IA were explored using western blot, enzyme-linked immunosorbent, real-time qPCR, immunohistochemistry, and flow cytometry. An H₂O₂-reduced human brain vascular smooth muscle cells (HBVSMC

SUBMITTER: NarenYa 

PROVIDER: S-EPMC11870834 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature