Ancient viral DNA in the human genome linked to neurodegenerative diseases.

ABSTRACT:

Background

Human endogenous retroviruses (HERVs) are sequences in the human genome that originated from infections with ancient retroviruses during our evolution. Previous studies have linked HERVs to neurodegenerative diseases, but defining their role in aetiology has been challenging. Here, we used a retrotranscriptome-wide association study (rTWAS) approach to assess the relationships between genetic risk for neurodegenerative diseases and HERV expression in the brain, calculated with genomic precision.

Methods

We analysed genetic association statistics pertaining to Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis, and Parkinson's disease, using HERV expression models calculated from 792 cortical samples. Robust risk factors were considered those th

SUBMITTER: Duarte RRR 

PROVIDER: S-EPMC11870845 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature