Association of genetic ancestry with pre-eclampsia in multi-ethnic cohorts of pregnant women.

ABSTRACT:

Objectives

Maternal self-reported ethnicity is recognised as a risk factor for pre-eclampsia in clinical screening tools and models. This study investigated whether ethnicity is acting as a proxy for genetic variants in this context.

Study design

A total of 436 women from multi-ethnic backgrounds recruited to two UK observational pregnancy hypertension cohort studies were genotyped. Genetically-computed individual ancestry estimates were calculated for each individual through comparison to the multi-ethnic 1000 Genomes reference panel genotypes. Regression models for pre-eclampsia using clinical risk factors including self-reported ethnicity with and without ancestry estimates were built and compared using Likelihood Ratio Tests (LRT).

Main outcome measures

Pre-eclamp

SUBMITTER: Conti-Ramsden F 

PROVIDER: S-EPMC11870846 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature