Frailty, high-sensitivity C-reactive protein and cardiovascular disease: a nationwide prospective cohort study.

ABSTRACT:

Background

This study aimed to investigate the complex associations of frailty and high-sensitivity C-reactive protein (hsCRP) with cardiovascular disease (CVD) through a nationwide prospective cohort, while also assessing the mediating associations.

Methods

According to critical criteria, a total of 5239 participants from the China Health and Retirement Longitudinal Study (CHARLS) in 2011 were ultimately enrolled in this study. Frailty was evaluated by the frailty index with 40 items, and CVD was defined as the presence of physician-diagnosed heart disease and/or stroke. A restricted cubic spline model, receiver operating characteristic curves, adjusted Cox proportional hazards regression, interaction analyses and mediation analyses were performed for association exploratio

SUBMITTER: Zheng L 

PROVIDER: S-EPMC11870887 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature