Unveiling the tissue-specific landscape of nuclear-encoded mitochondrial genes involved in amino acid  metabolism in buffalo.

ABSTRACT: Mitochondria play a pivotal role in energy production, metabolism, and cellular signaling, serving as key regulators of cellular functions, including differentiation and tissue-specific adaptation. The interplay between mitochondria and the nucleus is crucial for coordinating these processes, particularly through the supply of metabolites for epigenetic modifications that facilitate nuclear-mitochondrial interactions. To investigate tissue-specific mitochondrial adaptations at the molecular level, we conducted RNA sequencing data analyses of kidney, heart, brain, and ovary tissues of female buffaloes, focusing on variations in mitochondrial gene expression related to amino acid metabolism. Our analysis identified 82 nuclear-encoded mitochondrial transcripts involved in amino acid metabolis

SUBMITTER: Sadeesh EM 

PROVIDER: S-EPMC11870903 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature