Specific cognitive impairment predicts the neuropsychiatric symptoms in patient with mild cognitive impairment.

ABSTRACT:

Background

Neuropsychiatric symptoms (NPS) are common in mild cognitive impairment (MCI). However, knowledge is limited about the relationship of NPS, clinical factors, and cognition in MCI.

Methods

A total of 1099 dementia, 1323 MCI and 377 cognitively normal (CN) were selected from the Tongji Cohort Study of Aging. All participants underwent comprehensive clinical and neuropsychological assessment. NPS were evaluated by the Neuropsychiatric Inventory Questionnaire (NPI-Q). Logistic regression analyses were conducted to investigate the relationship between clinical factors, cognition and NPS.

Results

The NPS presented in 56.39% of MCI participants, and the NPI-Q scores of MCI was intermediate between CN and dementia. The most common NPS in MCI were depression (30.76%

SUBMITTER: Pan C 

PROVIDER: S-EPMC11870941 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature