A whole-body mechanistic physiologically-based pharmacokinetic modeling of intravenous iron.

ABSTRACT: Iron is essential for every cell of the mammalian organism. Iron deficiency is a major public health issue worldwide. Intravenous (IV) iron therapy has been used to treat anemia. However, IV iron therapy is known far away from ideal because the quantitative relationship between the pharmacokinetics and biodistribution of IV iron under different iron statuses remains unclear. Patients are known to suffer adverse effects from excessive iron accumulation. Our objective was to develop a physiologically based pharmacokinetic (PBPK) model of iron in mice and validate its application for predicting iron disposition in rats and humans. Previously published data on iron were collected for constructing the PBPK model of iron in mice, and then extrapolated to rats and humans based on physiologically

SUBMITTER: Fan X 

PROVIDER: S-EPMC11870943 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature