Can Non-Thymomatous Late-Onset Myasthenia Gravis Benefit From Thymectomy? A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Thymectomy is beneficial for treating early-onset acetylcholine receptor antibody-positive myasthenia gravis (MG); however, its effects on late-onset MG (LOMG) remain less well understood. Given the increasing incidence of MG among the population 50 years old and above, addressing the question of whether thymectomy is effective for this age group is critically important. This study aimed to assess the present evidence for the efficacy of thymectomy in LOMG and identify potential characteristics that may predict the treatment response.

Methods

Four electronic databases were searched from their inception to September 10, 2024. Six studies with both thymectomy and medical therapies in LOMG patients, along with another 14 studies with only a surgical group, were enrol

SUBMITTER: Chen J 

PROVIDER: S-EPMC11871088 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature