Anti-GAD Antibodies as an Etiology of Cerebral Cortical Encephalitis: 2 Case Reports.

ABSTRACT:

Introduction

Cerebral cortical encephalitis (CCE) has been recently described as an entity associated with anti-MOG antibodies and, in some cases, of anti-GABA_AR encephalitis. No clear association with other antibodies has been reported to date. We describe two cases of patients presenting clinical and radiological features of diffuse cortical encephalitis associated with anti-GAD antibodies.

Method

In two patients with CCE, screening for the presence of anti-GAD and other antibodies was performed, along with a complete workup for alternative diagnoses.

Results

Two patients showing clinical and radiological features of CCE were tested positive for anti-GAD antibodies. MRI scan revealed multiple bilateral areas of cortico-subcortical FLAIR hyperintensities.

SUBMITTER: Lemarchant B 

PROVIDER: S-EPMC11871092 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature