A new bicornuate model of rat uterus transplantation.

ABSTRACT:

Introduction

Uterus transplantation has revolutionized reproductive medicine for women with absolute uterine factor infertility, resulting in more than 40 reported successful live births worldwide to date. Small animal models are pivotal to refine this surgical and immunological challenging procedure aiming to enhance safety for both the mother and the child.

Material and methods

We established a syngeneic bicornuate uterus transplantation model in young female Lewis rats. All surgical procedures were conducted by an experienced and skilled microsurgeon who organized the learning process into multiple structured steps. Animals underwent meticulous preoperative preparation and postoperative care. Transplant success was monitored by sequential biopsies, monitoring graft viabil

SUBMITTER: Polenz D 

PROVIDER: S-EPMC11871102 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature