Cortisol and 10-Year Cognitive Decline in Older People From the General Population.

ABSTRACT:

Objective

The present study examined bidirectional effects between salivary cortisol and cognitive functioning over time. Furthermore, the role of the APOE-ɛ4 allele as a moderator of the associations was investigated.

Methods

Using a prospective population-based study, we analyzed data from 752 older adults followed up over 10 years. A random-intercept Cross-Lagged Panel Model was applied to each combination of one cortisol measure (at waking time, 30 min after waking, 11 am, 8 pm, cortisol awakening response, total daily output, and diurnal slope) and one cognitive measure (primary outcome: Clinical Dementia Rating Scale sum of boxes score, CDR-SB; secondary outcome: Mini-Mental State Examination) resulting in 14 (7 × 2) models.

Results

Between-person effects pointe

SUBMITTER: Amendola S 

PROVIDER: S-EPMC11871105 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature