Sex disparity in adult asthma-A potential immunomodulatory role of let-7 family microRNAs.

ABSTRACT:

Background

Sex differences have been reported in the incidence, prevalence and severity of asthma. Previous findings from animal models have revealed sex-related differences in inflammatory pathways that may contribute to asthma pathogenesis, but human studies are limited.

Methods

Airway and blood samples (n = 55 and n = 85 respectively) were collected from adult females and males with asthma and healthy subjects. Type 2 innate lymphoid cells (ILC2s), T helper (Th)2 cells and their expression of IL-33R/ST2 (ST2L) were evaluated by flow cytometry. IL-13, thymic stromal lymphopoietin (TSLP), IL-33 and soluble IL-33R/ST2 (sST2) were measured by ELISA. Let-7 miRNA expression in bronchial biopsies was determined by qPCR.

Results

Females with asthma reported more exacerbati

SUBMITTER: Malmhall C 

PROVIDER: S-EPMC11871111 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature