Toward human uterus tissue engineering: Uterine decellularization in a non-human primate species.

ABSTRACT:

Introduction

Uterus bioengineering offers a potential treatment option for women with uterine factor infertility and for mitigating the risk of uterine rupture associated with women with defective uterine tissue. Decellularized uterine tissue scaffolds proved promising in further in vivo experiments in rodent and domestic species animal models. Variations in the extracellular matrix composition among different species and adaptations of the decellularization protocols make it difficult to compare the results between studies. Therefore, we assessed if our earlier developed sodium deoxycholate-based decellularization protocol for the sheep and the cow uterus could become a standardized cross-species protocol by assessing it on the non-human primate (baboon) uterus.

Material and me

SUBMITTER: De Miguel-Gomez L 

PROVIDER: S-EPMC11871112 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature