Molecular imaging in hypertrophic cardiomyopathy: an exploratory study with 2-[¹⁸F]FDG and [¹³N]NH₃.

ABSTRACT:

Background

Hypertrophic Cardiomyopathy (HCM), a genetic disorder with diverse phenotypes, is associated with risks of heart failure and sudden cardiac death. While the condition involves multiple pathological pathways, including myocardial inflammation, increased workload, myocyte disarray, apoptosis, and fibrosis, the role of molecular imaging via PET-CT remains unexplored in this context. This study aimed to investigate the relationship between myocardial metabolism and perfusion using PET-CT in patients with non-obstructive HCM (NOHCM).

Results

Myocardial perfusion and metabolism were assessed using PET-CT with [¹³N]NH3 and 2-[¹⁸F]FDG uptake, respectively, in 30 NOHCM patients. Baseline measurements included maximal myocardial wall thickness (MMWT),

SUBMITTER: Ferreira MJ 

PROVIDER: S-EPMC11871154 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature