Abuse-deterrent wearable device with potential for extended delivery of opioid drugs.

ABSTRACT:

Purpose

Unethical attempts to misuse and overdose opioids have led to strict prescription limits, necessitating frequent hospital visits and prescriptions for long-term severe pain management. Therefore, this study aimed to develop a prototype wearable device that facilitates the extended delivery of opioid drugs while incorporating abuse-deterrent functionality, referred to as the abuse deterrent device (ADD).

Methods

The ADD was designed and fabricated using 3D-printed components, including reservoirs for the drug and contaminant, as well as an actuator. In vitro tests were conducted using a skin-mimicking layer and phosphate-buffered saline (PBS) to evaluate the drug release profile and the effectiveness of the ADD abuse-deterrent mechanism.

Results

Under simulated

SUBMITTER: Kim MJ 

PROVIDER: S-EPMC11871182 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature