Resveratrol does not mimic the positive effects of calorie restriction on lifespan in Microcebus murinus.

ABSTRACT: Resveratrol (RSV), a polyphenol with anti-aging properties affecting metabolism and energy balance, is considered as a mimetic candidate to calorie restriction (CR). However its potential effects on delaying the onset of age-related diseases and increasing longevity have not yet been demonstrated in non-obese models close to humans such as non-human primates. The longitudinal monitoring of cognitive and motor performances, occurrence of age-related pathologies, age-related brain atrophy and mortality was performed from adulthood to death in a cohort of male grey mouse lemurs (Microcebus murinus, N = 33), all receiving 105 kJ/day of food but with a subset of 18 animals receiving RSV (200 mg.kg^-1 body weight.day^-1). RSV supplementation improved cognitive and motor perfo

SUBMITTER: Pifferi F 

PROVIDER: S-EPMC11871233 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature